In "Hitman: Blood Money - Reprisal," players step into the shoes of Agent 47, a skilled assassin entangled in a dangerous game with a rival agency known as "The Franchise." The game challenges players to eliminate key figures within the shadowy conspiracy while utilizing various tools and tactics to maintain a low profile. With a focus on infiltration, execution, and evasion, players must navigate through missions with stealth and precision.

The game introduces new gameplay elements inspired by later titles in the Hitman series, offering a redesigned experience of the classic stealth-action game. Players can customize their gameplay experience with a touchscreen interface and gamepad support. The sandbox missions in Blood Money encourage creativity and experimentation, allowing players to approach objectives in multiple ways and strategize for optimal outcomes.

Enhanced features such as Instinct Mode provide players with valuable insights, highlighting targets and critical points of interest for executing stealthy kills and making swift getaways. With upgradable weapons, players can choose between silent assassinations, manipulating the environment for accidents, or engaging in direct confrontations. The game also offers improved situational awareness through a new Minimap and customizable controls, ensuring that players have the tools needed to succeed as a professional assassin.